Product Name: DARVIN

Type: Antibiotic Powder

COMPOSITION

Each 100 ml (or equivalent powder dosage) contains:

• Sulphaquinoxaline (USP) ...... 7.68 g
• Diaverdine ...... 1.92 g
• Excipients ...... q.s. to 100 ml

DESCRIPTION

DARVIN is a broad-spectrum antibiotic and anticoccidial powder containing the synergistic combination of Sulphaquinoxaline and Diaveridine. This formulation is specifically designed for the treatment and control of coccidiosis and bacterial infections in poultry

Sulphaquinoxaline: Sulphaquinoxaline is a sulfonamide antimicrobial agent with bacteriostatic activity against many Gram-positive and Gram-negative bacteria, as well as antiprotozoal (coccidiostatic) activity against Eimeria spp. . It acts by competitively inhibiting the enzyme dihydropteroate synthase, which is essential for the bacterial synthesis of dihydrofolic acid . By blocking this enzyme, it prevents the incorporation of para-aminobenzoic acid (PABA) into the folic acid molecule, leading to inhibition of bacterial and protozoal protein synthesis and nucleic acid production .

Diaveridine: Diaveridine is a diaminopyrimidine compound that acts as a dihydrofolate reductase (DHFR) inhibitor . It interferes with the conversion of dihydrofolic acid to tetrahydrofolic acid, a crucial step in the folate metabolism pathway .

Synergistic Mechanism: The combination of Sulphaquinoxaline and Diaveridine produces a synergistic effect . Sulphaquinoxaline blocks the initial step of folate synthesis, while Diaveridine inhibits the subsequent step . This dual blockade of the folate metabolic pathway results in enhanced antimicrobial and antiprotozoal activity compared to either agent used alone . Diaveridine also helps reduce the toxicity associated with sulfaquinoxaline administration .

INDICATIONS
DARVIN is indicated for the treatment and control of the following conditions in poultry:

Coccidiosis:

• Eimeria tenella (caecal coccidiosis)
• Eimeria necatrix (intestinal coccidiosis)
• Eimeria acervulina
• Eimeria maxima
• Eimeria brunetti
• Eimeria mivati

Bacterial Infections:

• Fowl Cholera – caused by Pasteurella multocida
• Fowl Typhoid – caused by Salmonella gallinarum
• Leucocytozoon Infection – protozoal infection in chickens
• Haemorrhagic Enteritis resulting from coccidial infections

DOSAGE & ADMINISTRATION

For oral administration via drinking water or feed. Prepare fresh solution daily. Body weight and water consumption should be determined as accurately as possible to ensure proper dosage .

Pulse Dosing Schedule:

• Treatment Period: 3 consecutive days of medication
• Rest Period: 2 days without medication
• Second Treatment: Additional 2-3 days of medication if necessary

Drinking Water Administration:

• Dissolve the prescribed amount in clean drinking water
• Medicated water should be the only source of drinking water during treatment
• Discard any remaining medicated water after 24 hours and prepare fresh solution

Feed Administration:

• Mix the required amount thoroughly into the final feed
• Ensure uniform mixing to avoid uneven distribution
• Use within 24-48 hours of mixing

WITHDRAWAL PERIODS

• Meat (Poultry): 7 to 10 days (depending on local regulations)
• Eggs: Not for use in laying birds producing eggs for human consumption – Egg withdrawal: 3-10 days

PRECAUTIONS & CONTRAINDICATIONS

• Do not use in birds with known hypersensitivity to sulfonamides or diaminopyrimidines
• Do not use in laying hens producing eggs for human consumption
• Do not use in animals with severe hepatic or renal impairment
• Do not administer concurrently with vitamin B complex or thiamine (vitamin B1), as these may interfere with the anticoccidial activity
• Do not exceed 3 consecutive days of treatment to prevent toxicity
• Side Effects: At recommended doses, side effects are rare. Potential side effects may include crystalluria, hematuria, and renal tubule blockage . Ensure adequate water intake during treatment.
• Operator Safety: Avoid inhalation and direct contact with skin or eyes. Use appropriate protective equipment when handling the product. Wash hands thoroughly after use.
• Environmental Precautions: Do not contaminate water sources with unused or expired product. Dispose of packaging responsibly according to local regulations.
• Storage: Store in a cool, dry place below 30°C, protected from light and moisture .
• Keep out of reach of children.

Target Species: Poultry (Broilers, Growers, Pullets, Turkeys)

Pack Sizes: 1 Liter

PRODUCT SUMMARY
DARVIN Powder Antibiotic Powder Each 100 ml Contains: Sulphaquinoxaline (USP)….7.68gm Diaverdine ……………………….… 1.92gm Livestock 1 Liter

FOR VETERINARY USE ONLY